A gene diagram and prognostic impact in pediatric AML patients with RUNX1 mutations. (A) A gene diagram depicting RUNX1 mutations in pediatric patients with AML (NCBI reference sequence; NM_001001890). (B) A VAF of 14 RUNX1 mutations. (C) A comparison of the OS and (D) EFS between patients with and without RUNX1 mutations. NRDBc, the C-terminal negative regulatory region for DNA binding; NRHc, the C-terminal negative regulatory region for heterodimerization; TAD, transcription activation domain.