Figure 5.
Cullin-RING ligase neddylation enzymes, COP9 signalosome and UBE2M, and the E2 enzymes, UBE2G1 and UBE2D3, regulate lenalidomide-induced CRL4CRBNactivity. Proteins in color scored in the genome-scale CRISPR-Cas9 screen.
Cullin-RING ligase neddylation enzymes, COP9 signalosome and UBE2M, and the E2 enzymes, UBE2G1 and UBE2D3, regulate lenalidomide-induced CRL4CRBNactivity. Proteins in color scored in the genome-scale CRISPR-Cas9 screen.