PGN infusion induces DIC in baboons. Time-course dynamics of clotting times, aPTT (A) and PT (B), and hemostatic biomarkers, TAT complexes (C), fibrinogen consumption (D), FDP (E) and D-dimers (F) generation were evaluated in baboons challenged with either high-dose (n = 5) or low-dose PGN (n = 3). Data are represented as mean ± SEM. Multiple comparisons were performed by 2-way repeated measures ANOVA followed by Holm-Sidak post hoc test and statistically significant changes from baseline (T0) are depicted: *P < .05; **P < .01; ***P < .001.