Figure 3.
CBS7/9 boundary plays a critical role in maintaining the posterior HOXA chromatin neighborhood. (A) qRT-PCR analysis of HOXA gene expression in MOLM13 cells compared with the WT control and the CBS7/9+/− clone (upper panel). RNA-seq reads of HOXA gene transcripts comparing WT and CBS7/9+/− MOLM13 cells (lower panel). (B) ChIP-seq analysis of H3K27me3, H3K4me3, and H3K79me2 modifications in the HOXA locus in MOLM13 cells compared with the WT control and the CBS7/9+/− clone. (C) ChIP-seq analysis of H3K27me3, H3K4me3, and H3K79me2 modifications in the HOXD locus in MOLM13 cells compared with the WT control and the CBS7/9+/− clone.

CBS7/9 boundary plays a critical role in maintaining the posterior HOXA chromatin neighborhood. (A) qRT-PCR analysis of HOXA gene expression in MOLM13 cells compared with the WT control and the CBS7/9+/− clone (upper panel). RNA-seq reads of HOXA gene transcripts comparing WT and CBS7/9+/− MOLM13 cells (lower panel). (B) ChIP-seq analysis of H3K27me3, H3K4me3, and H3K79me2 modifications in the HOXA locus in MOLM13 cells compared with the WT control and the CBS7/9+/− clone. (C) ChIP-seq analysis of H3K27me3, H3K4me3, and H3K79me2 modifications in the HOXD locus in MOLM13 cells compared with the WT control and the CBS7/9+/− clone.

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