MV release and PS exposure in CRP-activated platelets are shear dependent and require integrin α_IIbβ_3. (A) MV release from wild-type (WT) or β₃ knockout (KO) platelets stimulated with increasing doses of CRP (0.5, 0.75, and 1.0 µg/mL) with or without shear (shear rate 3000 s⁻¹). (B) PS exposure on WT or β₃ KO platelets stimulated with increasing doses of CRP (0.5, 0.75, and 1.0 µg/mL) with or without shear. Data are presented as mean ± standard error of the mean (n = 3-5). ****P < .0001.