Outcome of CRLF2-R patients enrolled in COG AALL0331. Kaplan-Meier estimates of EFS and OS of patients with Ph-like ALL and CRLF2-R compared with patients without a CRLF2-R (excluding BCR-ABL1) (A); positive (≥0.01%) vs negative MRD (<0.01%) at end of induction for patients with Ph-like ALL and a CRLF2-R (B).