Targetable kinase alterations in Ph-like ALL. (A) Summary of genetic subgroups in Ph-like ALL. (B) Frequency of targetable alterations according to the LDA Ph-like coefficient. CRLF2-R, IGH-CRLF2, and P2RY8-CRLF2; ABL1-class fusion, ZMIZ1-ABL1 and EBF1-PDGFRB; JAK2 fusion, ETV6-JAK2 and PAX5-JAK2; other kinase fusion, ETV6-NTRK3; other sequence mutation, IL7R, KRAS, and NRAS. (C) Distribution of kinase alterations by LDA value in SR and HR Ph-like ALL.⁹