The role of MGL in the clearance of VWF. VWF contains glycan structures (red dots) that are capped by sialic acids (blue triangles). Circulating VWF may lose some of the terminal sialic acids over time and becomes hyposialylated. Hyposialylated VWF is a target for the AMR on hepatocytes. However, in this issue, Ward and colleagues now show that MGL is also an active receptor for hyposialylated VWF, mediating rapid macrophage-mediated clearance. Interestingly, van Schooten et al⁵  reported previously that type 1 VWD is often associated with reduced sialylation of O-linked glycans and concomitant increased clearance (fast lane). It is therefore tempting to speculate that MGL also contributes to the increased clearance of such hyposialylated VWF in type 1 VWD.