Reductions in key pharmacodynamic markers of inhibition and proliferation in CLL cells from patients with RR CLL/SLL and TN CLL. Phosphorylation of AKT at S473 was measured by flow cytometry in CD19⁺/CD5⁺ CLL cells obtained from whole blood collected at baseline (0 h) and at 1 h and 24 h postdose on C1D1. Ki-67, a marker of cell proliferation, was measured by flow cytometry on CD19⁺/CD5⁺ CLL cells obtained from whole blood collected predose (0 h) on C1D1 and C2D1). All data shown as percent positive.