Figure 2.
Figure 2. Duvelisib induces cell-autonomous and -nonautonomous effects in TCL cell lines. (A) Expression pattern of the p110 isoforms α, δ, and γ; AKT; and phosphorylation status of AKT at Ser473 across 11 T- and NK-cell lymphoma cell lines. (B) Example of GR50 and GRmax calculations for duvelisib in OCI-LY13.2 cells. The day 0 value is indicated by the green box. (C) GR50 and GRmax values for the 11 lines treated with the indicated agents. Missing data bars indicate GR50 >10 µM. (D) Annexin V/7-AAD staining after 48 hours incubation with dimethyl sulfoxide (DMSO) or 1 µM duvelisib.

Duvelisib induces cell-autonomous and -nonautonomous effects in TCL cell lines. (A) Expression pattern of the p110 isoforms α, δ, and γ; AKT; and phosphorylation status of AKT at Ser473 across 11 T- and NK-cell lymphoma cell lines. (B) Example of GR50 and GRmax calculations for duvelisib in OCI-LY13.2 cells. The day 0 value is indicated by the green box. (C) GR50 and GRmax values for the 11 lines treated with the indicated agents. Missing data bars indicate GR50 >10 µM. (D) Annexin V/7-AAD staining after 48 hours incubation with dimethyl sulfoxide (DMSO) or 1 µM duvelisib.

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