Patient 2 timeline, clinical progression, vitreous tumor, and immunohistochemical stains demonstrating shift. (A) Timeline of case 2, including the evolution of the immunophenotypic switch, the diagnosis of intraocular involvement, and the treatment course. (B) An ill-defined red plaque with multiple follicular-based red papules present during initial consultation. (C) Slit lamp photograph of the right eye showing dense vitreous tumor cellular involvement behind the lens. The vitritis filled the entire vitreous cavity, but is only visible in this photograph in the area illuminated by the slit beam (arrows). (D-E) Immunohistochemical stains of cutaneous biopsy taken at time of intraocular diagnosis. Note the strong positivity for both CD4 (D) and CD8 (E) indicating a mixed immunophenotype of the cutaneous tissue, even at the same time that the intraocular tumor was CD4⁻/CD8⁺. Original magnification ×10 for panels D-E. R, right.