Consort diagram depicting enrollment, exclusion, and treatment realization. Overall chemoimmunotherapy realization: 86% of all patients received the complete number of treatment cycles, either 6 in stage III-IV or 4 of the planned cycles in stage I-II. A tumor lysis syndrome was observed in only 3 patients, which is less than 1%. Auto-SCT, autologous stem cell transplant; EN, extranodal involvement; MedTu, mediastinal tumor; PR, partial remission.