INK128 reduces IE of Hri^−/−–Fe mice. (A) Reticulocyte percentage in blood samples and (B) spleen weights of Wt–Fe and Hri^−/−–Fe mice treated with vehicle or INK128 for 3 days. (C-D) Percentages of Ter119⁺ cells in spleens and BM. P values denote the difference between vehicle and INK128 treatment of each genotype. *P < .05, **P < .01. (E) Representative Wright-Giemsa stained blood smears before (day 0) and after 3 days (day 3) of INK128 treatment. (F) Representative cell pellets of BM and spleen samples. (G) Erythroid differentiation of BM and spleen. (H) Representative cell morphology of BM and spleen samples stained with May-Grunwald-Giemsa. Three mice were used for each condition and genotype.