Lactadherin reduced cerebral edema and improved outcomes of FPI. (A) Representative topical and cross-sectional views of brains from a sham mouse (left) and from FPI mice preconditioned with PBS (middle) or lactadherin (right). (B-D) Representative fluorescence images of brain cryosections from a sham mouse and mice receiving lactadherin or PBS. (E) Levels (OD unite) of Evans blue in the supernatants of tissue homogenates from FPI mice receiving different treatments (n = 9, 1-way ANOVA). (F) Platelet counts at the baseline (white bars) and 3 hours after FPI (black bars) of sham mice and TBI mice preconditioned with PBS or lactadherin (n = 16, 1-way ANOVA). A Kaplan-Meier survival analysis (G, n = 18; P < .005 vs mice received PBS) and modified Neurological Severity Score (H, n = 18, 1-way ANOVA) of sham and FPI mice receiving PBS or lactadherin. (I) A Kaplan-Meier survival analysis of BDMV-infused and control mice (P < .005 vs mice that received PBS).