Clonal hematopoiesis with TP53 mutations. (A) Percentage of cases with clonal hematopoiesis due to TP53 mutations. (B) Percentage of cases with clonal hematopoiesis due to mutations in genes besides TP53. ****P < .001 compared with healthy donors. (C) Number of TP53 mutations per patient with SDS vs age. (D) Variant allele frequency (VAF) for R249Q TP53 in serial bone marrow samples obtained for patient SDS34. (E) The TP53 mutations, with the number of times the mutation was seen in parentheses. (F) Number of patients with severe neutropenia (ANC < 500 per mm³), mild/moderate neutropenia (ANC 500-1500 per mm³), or no neutropenia. (G) Number of patients with anemia. (H) Number of patients with thrombocytopenia. a.a., amino acid; n.t., nucleotide; pos, position.