Progression of disease within 24 months (POD24) is an accurate predictor of poor overall survival (OS). (A) Distribution of patients from the GLSG and BCCA cohorts according to the POD24 classifier. (B) Kaplan Meier curves for OS from risk-defining events for patients with or without POD24 of diagnosis (dashed lines) or 24 months of treatment initiation (solid lines) from the GLSG (left) and BCCA cohorts (right). Displayed statistics refer to POD24 status calculated from time of treatment initiation (ie, modified definition).