Purified hnDNA, but not mononucleosome particles, trigger TG in plasma. (A) TG generation performed in recalcified PFP containing hnDNA or recombinant mononucleosomes. (B) TG generation performed in recalcified PRP containing hnDNA or recombinant mononucleosomes. rmNucl, mononucleosomes consisting of reconstituted recombinant human histone proteins and DNA. The unit of rmNucl is expressed as the ratio of final concentrations of histones to DNA. Panels A and B are representative of 3 independent experiments.