Schematic overview of TIC. Trauma induces a laboratory-evident coagulopathy through a variety of different pathways, which is likely modulated by baseline patient factors such as genetics and comorbidities. Unfortunately, few causative relationships are currently known. TIC is a separate entity from iatrogenic causes of coagulopathy including hemodilution and preinjury anticoagulant therapy. Currently, the literature only identifies TIC based on laboratory abnormalities, and its relationship to true clinical coagulopathic bleeding is unknown.