Figure 3
![Figure 3. Transfused VWF fragments exhibit t1/2 of ∼1 to ∼4 hours (hrs). PPP isolated from hydrodynamically injected Vwf−/− mice (n = 5-11 mice per VWF fragment) by cardiac puncture was pooled and transfused into 4 to 9 naive Vwf−/− mice. Residual VWF levels (mean ± SD) in recipient mice were normalized to the 5-minute time point (set as 100% [%5min]). Measurements were nonlinearly regressed to predict the clearance of each FVIII-stabilizing VWF fragment (curves).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/124/3/10.1182_blood-2013-11-540534/4/445f3.jpeg?Expires=1723306828&Signature=ZGvwB7dIPfkFrzc02f7ikrjsMvNaJWyzuvo70DJCwg938gYXBW-99OgiyThrEkrZs1smr6cxpXl3AuGOm0G3MFrgwV-dGkPxQcg-s~cGQaJkXzJ5fneed2PUW3oEJVzsI8QBq2wnMUsOUa-ZJAYSaqLimB2HSxj7ecwlgNV0NjshHzLT22cTSF5ZIih8QsBNXOusOTlmUVq-KmOBEMbvlZZgHWizJ6LHLKLhuStPNLtAFF4tYns544o11F~FCX6qO3ikU2w03h9zMF2SBaH7pbkn-TE7z1m1hatluMexRSw4eyr24vOhtHP1U94ZlsKG8PmSFhqZcYKe4LlFebi0LA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Transfused VWF fragments exhibit t1/2 of ∼1 to ∼4 hours (hrs). PPP isolated from hydrodynamically injected Vwf−/− mice (n = 5-11 mice per VWF fragment) by cardiac puncture was pooled and transfused into 4 to 9 naive Vwf−/− mice. Residual VWF levels (mean ± SD) in recipient mice were normalized to the 5-minute time point (set as 100% [%5min]). Measurements were nonlinearly regressed to predict the clearance of each FVIII-stabilizing VWF fragment (curves).
