MDSC-like subsets accumulate in peripheral blood of DLBCL patients but only M-MDSCs correlate with the clinical status of DLBCL patients. (A) Neutrophils, immature granulocytes (Imm Gran), monocytes as determined on a complete blood count, and WBC counts are shown for 45 HD and 66 DLBCL samples. Box and whisker plots with the 10 to 90 percentiles and the outliers are shown. (B) DLBCL patients were separated in LR (n = 16) or HR (n = 34) groups based on the aaIPI score (<3 and ≥3, respectively). LMR and NLR ratio are shown. (C) (Left) G-MDSC and M-MDSC counts were performed in 23 HD and 31 DLBCL samples. (Right) Correlation (Spearman) between G-MDSC and Imm Gran counts and between M-MDSC and monocytes counts. (D) For 29 DLBCL samples, clinical information was available. (Top) Patients were separated in a LR (n = 12) or HR (n = 17) group based on the aaIPI score (<3 and ≥3, respectively). M-MDSCs are shown for these groups. (Bottom) Patients were split up between high (n = 14) and low (n = 15) count of M-MDSC (with a threshold at the median count), and the EFS probability was calculated for both groups with a log-rank test. *P < .05, **P < .01, ***P < .001.