Two functions for hTR. hTR and hTERT complex to form catalytically active telomerase to maintain telomeres. In this catalytically active conformation, hTR complexes with hTERT and other factors to elongate telomeres. hTR also functions in a catalytically inactive state (shown here as unbound to hTERT with a disprupted pseudoknot) to prevent apoptosis. In a catalytically inactive state, hTR may be able to bind other factors to protect from apoptosis. Dyskerin is depicted because it is necessary for hTR accumulation, but some other binding partner might be involved with hTR to prevent apoptosis. Red lines: template; green lines: Δ96-7 hTR mutant; orange lines: P6.1 stem disrupted by G305A.