Characterization of donor cell–induced leukemia. (A) Kaplan-Meier survival curve of recipient mice transplanted with Nras (dash), CM (solid), and Nras/CM (dotted) BM cells and Cre-activated after 2 weeks. The red arrow depicts the disease onset of a mouse with mixed leukemic and myeloproliferative cells. (B) FACS analysis of peripheral blood cells from control (top), representative leukemic moribund Nras/CM recipient mice (5/6), and the Nras/CM* (bottom) mouse with a mix of leukemia and myeloproliferative phenotypes. (C) Representative H&E-stained histology sections of BM, spleen, and liver from control and moribund Nras/CM recipient mice (Nras/CM transplantation LK). The scale bars in the BM and spleen represent 50 μm; in the liver 100 μm.