UHRA-10 delays time to occlusion in a mouse carotid artery model of thrombosis. Artery patency was monitored by Doppler flow probe following induction of FeCl₃-mediated injury and plotted here vs time in black for saline control, orange for unfractionated heparin, and blue for UHRA-10. Both heparin and UHRA-10 significantly delayed median time to occlusion in a dose-dependent manner (P < .0001). Heparin at 200 U/kg was not significantly more effective than UHRA-10 at 100 mg/kg at maintaining artery patency (P = .85), whereas both treatment conditions significantly increased median patency time vs saline control (P = .0004 for UHRA-10 and P = .007 for heparin). UHRA-10 at 200 mg/kg or heparin at 1000 U/kg resulted in 100% patency over the 30-minute period for all mice (n = 7 for all conditions). Statistical significance was assessed by log-rank analysis.