Superenhancers in Tfh cells. (A) Distribution of H3K27Ac normalized ChIP-seq signal across Tfh cell enhancers. Superenhancers are shown in red. Select superenhancer-associated genes are labeled. (B) Representative Tfh cell superenhancers associated with immune-related SNPs at 3 gene loci: MAF, BATF, and IRF4. The called superenhancer is denoted by the thick blue line at the top of the figure. The associated SNP is shown below the superenhancer line. The track of H3K27 acetylated chromatin is shown above the associated gene locus.