RXR loss induces in vivo differentiation. (A) Left panel: Survival of mice inoculated with APL cells derived from RXRA^f/f RXRB^f/f RXRG^−/− PML/RARA FLT3-ITD Cre-ERT2 mice, untreated or treated with 4-OHT. Right panel: Cherry-positive cells after 5 days of treatment. After 2 days of treatment with 4-OHT or RA in vivo, spleen cells were GFP sorted and analyzed for RXRA and RXRB ablation (B), protein expression (black dividing lines show grouping of images from different parts of the same exposed film) (C), differentiation by MGG staining (top bar, 10 µm) (D), and flow cytometry (E-F).