DLE-HuM195 facilitates serial killing by NK cells by rapidly shortening the kinetics of target apoptosis. Cumulative association/decay curves (jagged lines) of (A) t_Seek, (B) t_Contact, and (C) t_Death for each single serial killer NK cell in interaction with multiple targets (2-3 targets). The solid lines represent the best-fit line modeled using either 2-phase or single-phase decay/associations. The parameters obtained from the curve fit are shown in supplemental Table 3. These data are derived from a total of 133 serial killer NK cells interacting with DLE-Targets and 97 serial killer NK cells interacting with wt-Targets. P values were calculated for each panel, as listed in supplemental Table 1 (P₂₅-P₃₂).