Figure 4
Figure 4. Recovery of antiviral immune responses after iC9-T-cell infusion and administration of AP1903. Patients 1 (A-B), 2 (C-D), and 5 (E-F) had viral reactivation and also received AP1903 to control acute GvHD. Left panels (A,C-D) illustrate the viral load for each single patient at multiple times; right panels (B,D-F) illustrate the quantification of pathogen-specific T cells detected either by IFN-γ ELIspot or intracellular staining in the CD3+CD19+ and CD3+CD19− T cells at each time.

Recovery of antiviral immune responses after iC9-T-cell infusion and administration of AP1903. Patients 1 (A-B), 2 (C-D), and 5 (E-F) had viral reactivation and also received AP1903 to control acute GvHD. Left panels (A,C-D) illustrate the viral load for each single patient at multiple times; right panels (B,D-F) illustrate the quantification of pathogen-specific T cells detected either by IFN-γ ELIspot or intracellular staining in the CD3+CD19+ and CD3+CD19 T cells at each time.

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