CD100 frequency and gMFI is not significantly modified by sustained ART but reconstitutes CD100⁺ naive CD8⁺ T cells. (A) Representative dot plot depicting the different CD8⁺ T-cell memory populations (TCM indicates central memory T cell; TEM, effector memory T cell; and TEMRA, terminally differentiated effector memory T cell). (B) Absolute numbers of CD100⁺CD8⁺ T cells, (C) percentage of CD100 expression, and (D) CD100 gMFI within each memory subset in HCs, untreated HIV-1–infected subjects (HIV⁺ ART⁻), and treated HIV-1–infected subjects (HIV⁺ ART⁺). Statistical analysis was performed using Kruskal Wallis tests with Dunn posttest (*P < .05, **P < .01, and ***P < .001).