American Society of Hematology

Figure 6

$Figure 6. Effect of RAP-536 on bone in Hbbth1/th1 mice. Hbbth1/th1 mice (3-4 months old) were treated with RAP-536 or vehicle as in Figure 2, and age-matched wild-type mice treated with vehicle were used as additional controls. (A) BMD (n = 8-13 mice per group). (B-D) BV/TV, TbN, and TbTh (n = 4-6 mice per group). (E) Representative 3-dimensional images of proximal tibiae generated from microcomputed tomography analysis. Data are means ± SEM. #P < .05 and ##P < .01 vs wild type; *P < .05, **P < .01, and ***P < .001, RAP-536 vs vehicle. BMD, bone mineral density; BV/TV, bone volume fraction; TbN, trabecular number; TbTh, trabecular thickness.$

Effect of RAP-536 on bone in Hbb^th1/th1 mice.Hbb^th1/th1 mice (3-4 months old) were treated with RAP-536 or vehicle as in Figure 2, and age-matched wild-type mice treated with vehicle were used as additional controls. (A) BMD (n = 8-13 mice per group). (B-D) BV/TV, TbN, and TbTh (n = 4-6 mice per group). (E) Representative 3-dimensional images of proximal tibiae generated from microcomputed tomography analysis. Data are means ± SEM. ^#P < .05 and ^##P < .01 vs wild type; *P < .05, **P < .01, and ***P < .001, RAP-536 vs vehicle. BMD, bone mineral density; BV/TV, bone volume fraction; TbN, trabecular number; TbTh, trabecular thickness.

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