Figure 4
![Figure 4. Duplication of 2p16 in four lymphomas. (A) Schematic representation of chromosome 2, with the various duplicated regions spanning the 2p16 chromosomal band in samples P3-L1, P4-L1, P4-L2, and P5L1. The expanded region is indicated by a large blue column. (B) Involvement of the REL locus in IL-10R deficiency-associated lymphomas, as detected by FISH. The FISH analysis (using an RP11-1118K19 probe for the REL locus [red signals] and a chromosome 2 centromere probe [green signals]) revealed duplication of REL in metaphase spread and interphase nuclei from P3-L1.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/122/23/10.1182_blood-2013-06-508267/4/3713f4.jpeg?Expires=1722679083&Signature=d6Ig5w0tr5qDzKqHx73ruxyT8gWVIBL42tzV1rxMVpZNZU~QIVNOuc8M1ZNZ34DULoO1TutahjDskFnPLidKnGC90DYxXgCWxbR~LCe5awiYWrVQxg-fr1xgpr-YsioMsUMSJLuQnMZc9VRbqcLhZPNhuxGq110ON0Y~IA4fT1-L7kltCodkBrOMznVoL54ZubhGRqpuWjBOz6mqUozL0cwgY26847~e8ChTCicqeVBhP4CBwkg2FZ9EoCsZvoFB8NI5PXL~E0ECBWH1QetFvZkl36k~miIkA1zwK7ENzsLIDWJxHIPff3sXp2o2zPKTwucPdFGTd3YSbkpMxsBXfA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Duplication of 2p16 in four lymphomas. (A) Schematic representation of chromosome 2, with the various duplicated regions spanning the 2p16 chromosomal band in samples P3-L1, P4-L1, P4-L2, and P5L1. The expanded region is indicated by a large blue column. (B) Involvement of the REL locus in IL-10R deficiency-associated lymphomas, as detected by FISH. The FISH analysis (using an RP11-1118K19 probe for the REL locus [red signals] and a chromosome 2 centromere probe [green signals]) revealed duplication of REL in metaphase spread and interphase nuclei from P3-L1.
