Figure 6
Figure 6. miR-145 promotes differentiation specifically in 5q− MDS hematopoietic progenitors. CD34+ cells from bone marrow aspirates of patients with 5q− syndrome and MDS patients without 5q deletions were infected with a lentivirus expressing miR-145 or an shRNA-targeting Renilla luciferase (shluc). In patients with 5q deletions (shown in red), miR-145 overexpression increased erythroid relative to megakaryocytic differentiation. No consistent changes in erythroid relative to megakaryocytic differentiation were observed with miR-145 overexpression in patients lacking 5q deletions (shown in blue). The difference between the groups was statistically significant (P = .0005 by 2-way ANOVA), and the pairwise differences in erythroid relative to megakaryocytic differentiation in the 5q− MDS samples were statistically significant by the Student t test. Values are mean ± SEM (n = 3) with propagated error. *P < .05.

miR-145 promotes differentiation specifically in 5q− MDS hematopoietic progenitors. CD34+ cells from bone marrow aspirates of patients with 5q− syndrome and MDS patients without 5q deletions were infected with a lentivirus expressing miR-145 or an shRNA-targeting Renilla luciferase (shluc). In patients with 5q deletions (shown in red), miR-145 overexpression increased erythroid relative to megakaryocytic differentiation. No consistent changes in erythroid relative to megakaryocytic differentiation were observed with miR-145 overexpression in patients lacking 5q deletions (shown in blue). The difference between the groups was statistically significant (P = .0005 by 2-way ANOVA), and the pairwise differences in erythroid relative to megakaryocytic differentiation in the 5q− MDS samples were statistically significant by the Student t test. Values are mean ± SEM (n = 3) with propagated error. *P < .05.

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