Figure 7
Figure 7. The S1P1 agonist SEW2871 enhances AMD3100-mediated HSC mobilization. (A) Representative scatter plots showing the contribution of donor (CD45.2, RFP−), recipient (CD45.1+), and competitor (CD45.2, RFP+) cells. (B) The percentage contribution to hematopoiesis in recipient mice receiving PBMCs from placebo- or SEW2871-treated donors mobilized with AMD3100 is shown. The mean and standard error in recipient animals are shown. (C) Proportion of B cells, T cells, and granulocytes within the donor (CD45.2+, RFP−)–derived population. Data from a single transplantation experiment are shown.

The S1P1 agonist SEW2871 enhances AMD3100-mediated HSC mobilization. (A) Representative scatter plots showing the contribution of donor (CD45.2, RFP−), recipient (CD45.1+), and competitor (CD45.2, RFP+) cells. (B) The percentage contribution to hematopoiesis in recipient mice receiving PBMCs from placebo- or SEW2871-treated donors mobilized with AMD3100 is shown. The mean and standard error in recipient animals are shown. (C) Proportion of B cells, T cells, and granulocytes within the donor (CD45.2+, RFP−)–derived population. Data from a single transplantation experiment are shown.

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