RVSP pressure, Fulton index, and cardiac output in L1Cre(−)BMPR2^f/f and L1Cre(+)Bmpr2^f/f mice treated with vehicle or SCH527123. L1Cre(−)Bmpr2^f/f mice or L1Cre(+)Bmpr2^f/f mice were treated with vehicle or the CXCR1/2 antagonist SCH527123 for 21 days after which RVSP levels (A), Fulton indexes (B), and cardiac output (C) were assessed. Data are the mean ± SEM for minimum of 8 animals per group. *P < .05, **P < .01, ***P < .001 compared with L1Cre(+)Bmpr2^f/f mice treated with vehicle by Dunnett test.