Plerixafor normalizes absolute blood leukocyte counts in patients with WHIM syndrome. All data collected from all 3 patients studied (P1, P2, and P3) are shown. Each point represents a single value obtained from that time point. Time zero is defined as the first day of plerixafor administration. Arrows indicate the time when the indicated dose of plerixafor in mg/kg was administered subcutaneously to the patient (Figure 1). Not shown: a sham saline injection of the same volume as the lowest dose was given on day −1 and as the greatest dose on day +7. WBC indicates white blood count; ALC, absolute lymphocyte count; ANC, absolute neutrophil count, and AMC, absolute monocyte count.