Deletion of Tet2 promoted the proliferative capacity of BM cells in vivo and Tet2 deletion induced-phenotype is cell-autonomous. Recipient mice receiving 1 × 10⁶ BM cells each from B6SJL mice (CD45.1) and 6- to 7-week-old WT, Tet2^+/− or Tet2^−/−, mice (CD45.2) were killed 2 or 6 months after transplantation. (A) The ratio of CD45.2⁺ versus CD45.1⁺ BM cells in each recipient mice were examined at 2 or 6 months after transplantation (mean ± SD of 3-7 animals). (B-C) The lineage distribution within the CD45.2⁺ cells in the BM of the recipient mice 6 months after receiving WT, Tet2^+/−, or Tet2^−/− BM cells (B). Flow cytometric analysis of representative recipient mice 6 months after receiving WT or Tet2^−/− BM cells (C). Histogram shows the percentage of CD45.2⁺ cells in the BM. (D-E) blood smear (May-Giemsa staining, D) and spleen weight/size (E) of representative mice receiving WT or Tet2^−/− (arrows indicate monocytes). BM cells are shown.