Figure 3
Figure 3. Cumulative frequency of patients having developed lymphoproliferation and autoimmunity as a function of age. (A) Splenomegaly precedes the development of lymphadenopathy and autoimmune manifestations. (B) Lymphodemopathy develops in 72% of patients. (C) Autoimmunity occured in 75% of patients. ++ indicates lymphadenopathy > 2 cm and < 5 cm; +++, lymphadenopathy > 5 cm; and ADP, lymphadenopathy.

Cumulative frequency of patients having developed lymphoproliferation and autoimmunity as a function of age. (A) Splenomegaly precedes the development of lymphadenopathy and autoimmune manifestations. (B) Lymphodemopathy develops in 72% of patients. (C) Autoimmunity occured in 75% of patients. ++ indicates lymphadenopathy > 2 cm and < 5 cm; +++, lymphadenopathy > 5 cm; and ADP, lymphadenopathy.

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