Figure 2
Figure 2. Identification of the Pknox1 mutants capable of accelerating Hoxa9-induced leukemia development. (A) Survival curve of mice that received a transplantation of bone marrow cells transduced with Hoxa9, or Hoxa9 plus Pknox1 mutants, or Hoxa9 plus wild-type Meis1 or Pknox1, or control (Gfp) and various TALE cDNAs alone. (B) AML latency in groups of mice identified on the top. *P < .0001, as determined by unpaired 2-tailed Student t test, compared with mice that received Hoxa9-transduced cells. #P = .024, as determined by unpaired 2-tailed Student t test, comparing mice that received Hoxa9 + Meis1 and Hoxa9 + Pknox1-MC-transduced cells.

Identification of the Pknox1 mutants capable of accelerating Hoxa9-induced leukemia development. (A) Survival curve of mice that received a transplantation of bone marrow cells transduced with Hoxa9, or Hoxa9 plus Pknox1 mutants, or Hoxa9 plus wild-type Meis1 or Pknox1, or control (Gfp) and various TALE cDNAs alone. (B) AML latency in groups of mice identified on the top. *P < .0001, as determined by unpaired 2-tailed Student t test, compared with mice that received Hoxa9-transduced cells. #P = .024, as determined by unpaired 2-tailed Student t test, comparing mice that received Hoxa9 + Meis1 and Hoxa9 + Pknox1-MC-transduced cells.

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