Three-point bending mechanical testing. (A) Representative examples of 3-point bending load-deflection curves until fracture obtained for WT, oim, and oim+IUT femurs: stiffness (S), ultimate force (F_ult), yield force (F_yield), and total and plastic work to fracture are indicated. (B) Box-plot of the ratio of plastic/total work to fracture. ***P < .001 (significant difference vs WT group). ††P < .01 (significant difference vs oim group).