Comparative oncogenomics of SB-induced T-cell lymphomas. (A) Global gene expression was analyzed in a set of 7 Vav-SB and 7 CD4-SB tumors. Unsupervised clustering analysis was performed using expression data from a set of 40 genes that distinguished typical T-ALL from ETP-ALL.³⁴  (B) Global gene expression analysis identified 2 gene sets that were up-regulated in either Vav-SB or CD4-SB tumors. Gene-set enrichment analysis showed that genes up-regulated in CD4-SB are enriched in ETP-ALL samples (blue arrows) while the Vav-SB gene set is enriched in typical T-ALL samples.