Influence of target INR on weekly warfarin maintenance dose (mg) by univariate analysis. Target INR was of 2.2 in patients with total cavopulmonary connection; 2.5 in those with aortic valve replacement, dilated cardiomyopathy, coronary aneurysms after Kawasaki disease, or extracardiac diseases; and of 3.3 in those with mitral valve replacement.