GSH/GSSG ratio in patients with ITP and controls. The concentrations of GSH and GSSG in whole blood were measured in patients with ITP and pediatric healthy controls; thereafter, the GSH/GSSG ratio was calculated for each sample and the unpaired t test was performed to compare the GSH/GSSG ratio between groups (mean ± SEM). (A) The whole blood GSH/GSSG ratio is significantly lower in patients with ITP in general (P < .02), indicating a higher oxidative stress state compared with healthy controls. The GSH/GSSG ratio is also significantly lower in chronic patients with ITP (P < .02) compared with healthy controls. The overall Bonferroni-corrected P value is < .05. (B) The GSH/GSSG is significantly higher in patients with recent treatments (within 1 month of sample collection) compared with patients without recent treatments (P = .0035).