In vivo thrombosis and in vitro coagulation in STAT5-deficient mice. (A) STAT5g male (- - -), STAT5g female (gray - - -), control male (—), and control female (gray —) mice were injected with 2.0 μL/g 1:40 TF dilution in a PE model of thrombosis. STAT5g males and females had reduced survival and shortened median survival times compared with sex-matched controls. No differences were found between genotype-matched males and females. (B) Whole blood was isolated from STAT5g male (○; n = 10), STAT5g female (□; n = 8), control male (●; n = 9), and control female (■; n = 14) mice. STAT5g mice had shortened TF-triggered clotting times compared with sex-matched controls. **P < .01, ***P < .001; 1-way ANOVA with Bonferroni post test. (C) STAT5l male (- - -), STAT5l female (gray - - -), control male (—), and control female (gray —) mice were injected with TF as in panel A. STAT5l males and females had reduced survival and shortened median survival times compared with sex-matched controls. No differences were found between genotype-matched males and females. (D) Whole blood was isolated from STAT5l male (○; n = 9), STAT5l female (□; n = 7), control male (●; n = 39), and control female (■; n = 38) mice. STAT5l mice had shortened TF-triggered clotting times compared with sex-matched controls. ***P < .001; 1-way ANOVA with Bonferroni post test.