Phosphoprotein kinetic profiles of AML patient samples: frequency analysis. (A-B) The frequency of blast cells that are not positive for any of the 3 downstream markers are plotted with the frequency at t = 0 set to 100%. (C-F) Actual frequencies (in percentage) of cells positive for each marker at time t. Gray zones represent 95% CI for normal blast cell response; and black line, the center (mean) of that distribution. Arrows point to high constitutive activity for AML3. represents AML2; □, AML3; ⊠, AML1; ⊡, AML5; and , NBM.