Development γδ T-cell lymphoma in Id3^−/− mice. (A-B) Flow cytometric analysis of the lymphomatous cells in a representative Id3^−/− mouse (mouse no. 44). The lymphomatous cells are γδTCR⁺CD3⁺, but αβTCR⁻ (A, R1); The gated R2 area represents the non-γδ T cells. γδ T-cell lymphoma cells (R1) were seen in the lymph nodes (LN), thymus (thy), bone marrow (BM), and liver (liv) of Id3^−/− mice (B). (C) The survival curve of Id3^−/− mice. Control mice (Id3^+/+ and ^+/−, n = 50 mice); Id3^−/− mice with lymphoma (^−/− lymphoma, n = 38 mice); Id3^−/− mice without lymphoma (^−/− not lymphoma, n = 104 mice). ** P < .01.