Histologic analysis of hearts and lungs of HA mice overexpressing mFVIIa-VEAY. Fibrin(ogen) immunohistochemical staining in the heart (A-B) showing visible thrombi in the atria. (C-F) Immunofluorescent staining for fibrin(ogen) in the lungs of AAV-mFVIIa-VEAY HA–treated mice (C-E) showing fibrin(ogen) deposition in the lung parenchyma in contrast to untreated HA control mice (F). Scale bars, 500 μm (A-B) and 50 μm (C-F).