American Society of Hematology

Figure 4

$Schematic figure of “in situ” mantle cell lymphoma (MCL) and early involvement of overt MCL; immunophenotype in the box. (A) Schematic figure of “in situ” MCL in which lymphoma cells are restricted to the inner zone of the mantle, pattern A (“in situ” MCL). (B) Lymphoma involvement is limited to the mantle zone of a secondary follicle with minimal expansion of this structure. Only a fraction of mantle cells expresses Cyclin D1, pattern B (“in situ” MCL?). (C) Schematic figure of early involvement of overt MCL showing that the lymphoma cells completely involve the expanded mantle zone of the follicle, pattern C (overt MCL). Immunoperoxidase, hematoxylin counterstain. (B) Images were taken using a Nikon Eclipse 80i microscope (Nikon) with a Plan Fluor 20×/0.50 objective and Nikon digital sight DS-Fi1 camera equipped with control unit-DS-L2 (Nikon). Images were assembled using Adobe Photoshop 6 (Adobe Systems).$

Schematic figure of “in situ” mantle cell lymphoma (MCL) and early involvement of overt MCL; immunophenotype in the box. (A) Schematic figure of “in situ” MCL in which lymphoma cells are restricted to the inner zone of the mantle, pattern A (“in situ” MCL). (B) Lymphoma involvement is limited to the mantle zone of a secondary follicle with minimal expansion of this structure. Only a fraction of mantle cells expresses Cyclin D1, pattern B (“in situ” MCL?). (C) Schematic figure of early involvement of overt MCL showing that the lymphoma cells completely involve the expanded mantle zone of the follicle, pattern C (overt MCL). Immunoperoxidase, hematoxylin counterstain. (B) Images were taken using a Nikon Eclipse 80i microscope (Nikon) with a Plan Fluor 20×/0.50 objective and Nikon digital sight DS-Fi1 camera equipped with control unit-DS-L2 (Nikon). Images were assembled using Adobe Photoshop 6 (Adobe Systems).

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