The frequency of circulating plasmablasts and plasma cells is not impaired in persons who have undergone splenectomy. Normal frequencies of CD19⁺/CD20⁻/CD27^high plasmablasts and plasma cells¹  among CD19⁺ B cells were detectable in 2 persons who underwent a splenectomy (A-B). These plasmablasts and plasma cells show characteristics of homeostatic mucosal plasmablasts in that they produce of IgA (C-D) and express β₇ integrin but rarely CD62L (E-F). Frequencies indicate proportions of gated cells among the total cell number shown in each dot plot.