NKG2D signaling is insufficient to cause rejection of MHC class I–matched BM. (A) B6 BM was transplanted into F1 recipients. NS indicated no significant difference to IgG control group. (B) BALB/c BM was transplanted into F1 recipients. *P < .008 for anti-Ly49D–treated versus control IgG group and significantly less than other 3 treated groups; P < .008. (C) Transplantation of (BALB/c × C.B10) F1 BM into CB6F1 recipients. Groups consisted of 4-5 mice treated with the reagents noted on the y-axis; “combo” refers to both anti-NKG2D and anti-Ly49D+Ly49A given simultaneously. Error bars represent SEM. Data shown are representative of 3 independent experiments.