EZH2 target promoters are less DNA-methylated than nontargets in GC B cells. This figures shows the distribution of DNA methylation values (HELP log-ratios) for all EZH2 target promoters (red) and nontargets (black) represented on our HELP arrays. The HELP assay was performed from tonsil DNA from 8 healthy patients as described previously²⁶  and using a high density oligonucleotide microarray representing 50 000 CpGs across approximately 14 000 promoters. Methylation profiles for the 8 patients were averaged out. Importantly, in HELP, higher and positive HELP log-ratios correspond to lower DNA methylation.