CCR7^−/−→WT chimeras have decreased proinflammatory cytokine levels 48 hours after conidial challenge compared with WT→WT chimeras. Lethally irradiated WT mice reconstituted with WT or CCR7^−/− HSCs and MPCs were infected with 2.0 × 10⁶ conidia 14 days after HSCT and analyzed 48 hours later. (A) RNA levels were determined by real-time PCR. Values represent the fold change of infected mice, compared with uninfected mice 16 days after HSCT. (B) Cytokine and chemokine levels were determined using a Bioplex multiplex assay; all values are represented as picograms per milliliter (n = 4 mice per uninfected group; 8 mice per conidia-challenged group). *P < .05, when comparing WT and CCR7^−/−→WT chimeras after conidia challenge.